×
Entrez Id:
1021
Gene Symbol:
CDK6
CDK6
0.310
AlteredExpression
disease
BEFREE
Here, we show that microRNA-200a decreases CDK6 expression and thus reduces the response of CDK4/6 inhibitor in highly proliferative metastatic melanoma .
28526299
2017
×
Entrez Id:
5587
Gene Symbol:
PRKD1
PRKD1
0.310
Biomarker
disease
BEFREE
In conclusion, our study suggests, for the first time, that while cPKCs don't embody a pertinent therapeutic target, inhibition of PKD1 represents a novel attractive approach for the treatment of metastatic melanoma .
28056869
2017
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.310
Biomarker
disease
BEFREE
By somatically inactivating Lkb1 with K-Ras activation (±p53 loss) in murine melanocytes, we observed variably pigmented and highly metastatic melanoma with 100% penetrance.
22698401
2012
×
Entrez Id:
4293
Gene Symbol:
MAP3K9
MAP3K9
0.310
GeneticVariation
disease
BEFREE
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
22197930
2011
×
Entrez Id:
2043
Gene Symbol:
EPHA4
EPHA4
0.310
Biomarker
disease
BEFREE
Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma .
9185712
1997
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.310
GeneticVariation
disease
UNIPROT
×
Entrez Id:
5587
Gene Symbol:
PRKD1
PRKD1
0.310
GeneticVariation
disease
UNIPROT
×
Entrez Id:
1021
Gene Symbol:
CDK6
CDK6
0.310
GeneticVariation
disease
UNIPROT
×
Entrez Id:
4293
Gene Symbol:
MAP3K9
MAP3K9
0.310
GeneticVariation
disease
UNIPROT
×
Entrez Id:
2043
Gene Symbol:
EPHA4
EPHA4
0.310
GeneticVariation
disease
UNIPROT
×
Entrez Id:
22983
Gene Symbol:
MAST1
MAST1
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
3000
Gene Symbol:
GUCY2D
GUCY2D
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
11184
Gene Symbol:
MAP4K1
MAP4K1
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
84446
Gene Symbol:
BRSK1
BRSK1
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
7273
Gene Symbol:
TTN
TTN
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
23178
Gene Symbol:
PASK
PASK
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
389840
Gene Symbol:
MAP3K15
MAP3K15
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
202374
Gene Symbol:
STK32A
STK32A
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
57144
Gene Symbol:
PAK5
PAK5
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
4919
Gene Symbol:
ROR1
ROR1
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
2046
Gene Symbol:
EPHA8
EPHA8
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
9475
Gene Symbol:
ROCK2
ROCK2
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
9149
Gene Symbol:
DYRK1B
DYRK1B
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
658
Gene Symbol:
BMPR1B
BMPR1B
0.300
GeneticVariation
disease
UNIPROT
×
Entrez Id:
150094
Gene Symbol:
SIK1
SIK1
0.300
GeneticVariation
disease
UNIPROT